| 货号 | 70265-10g |
| 描述 | 5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 µM, respectively.1 In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2(PGE2) production, but does reduce leukotriene B4(LTB4) synthesis approx. 50%.2 In ionophore-stimulated human leukocytes, 400 µM 5-ASA reduces LTB4 production approximately 20%.3 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 µM.4 |
| 别名 | 5-ASA;Mesalazine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Warner, T.D.,Giuliano, F.,Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proceedings of the National Academy of Sciences of the United States of America 96(13), 7563-7568 (1999). 2.Schmidt, C.,Fels, T.,Baumeister, B., et al. The effect of 5-aminosalicylate and para-aminosalicylate on the synthesis of prostaglandin E2 and leukotriene B4 in isolated colonic mucosal cells. Current Medical Research and Opinion 13, 417-425 (1996). 3.Tornhamre, S.,Edenius, C.,Smedegård, G., et al. Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. European Journal of Pharmacology 169, 225-234 (1989). 4.Berry, C.N.,Hoult, J.R.S.,Peers, S.H., et al. Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues. Biochemical Pharmacology 32, 2863-2871 (1983). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥99% |
| 计算分子量 | 153.1 |
| 分子式 | C7H7NO3 |
| CAS号 | 89-57-6 |
| 稳定性 | ≥ 1 year |
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