LED209
货号：
16844-1mg 基本售价：
154.0 元 规格：
1 mg
产品信息
概述| 货号 | 16844-1mg |
| 描述 | Bacterial pathogens require the conserved membrane histidine sensor kinase (QseC) to detect both host-derived adrenergic signals and the bacterial autoinducer-3 (AI-3), thus activating a signaling cascade that induces virulence gene expression.1 LED209 is a potent QseC inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro.2 While LED209 inhibits virulence of enterohemorrhagic E. coli,S. typhimurium, and F. tularensis, it does not inhibit pathogen growth, a highly desirable feature of antimicrobial agents to prevent drug resistance.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sperandio, V.,Torres, A.G.,Jarvis, B., et al. Bacteria-host communication: The language of hormones. Proceedings of the National Academy of Sciences of the United States of America 100(15), 8951-8956 (2003).
2.Rasko, D.A.,Moreira, C.G.,Li, D.R., et al. Targeting QseC signaling and virulence for antibiotic development. Science 321, 1078-1080 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.5 |
| 分子式 | C19H17N3O2S2 |
| CAS号 | 245342-14-7 |
| 稳定性 | ≥ 2 years |
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