TMS
货号：
10038-1mg 基本售价：
154.0 元 规格：
1 mg
产品信息
概述| 货号 | 10038-1mg |
| 描述 | CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.1 It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.1 In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.2 |
| 别名 | 2,3,4,5-Tetramethoxystilbene; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, S.,Ko, H.,Park, J.E., et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. Journal of Medicinal Chemistry 45, 160-164 (2002).
2.Nam, K.A.,Kim, S.,Heo, Y.H., et al. Resveratrol analog, 3,5,2,4-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Archives of Pharmacal Research 24(5), 441-445 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.4 |
| 分子式 | C18H20O4 |
| CAS号 | 24144-92-1 |
| 稳定性 | ≥ 2 years |
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