| 货号 | 80210-1000mg |
| 描述 | L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA).1 L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively.2,3,4 The reported Ki value for the inhibition of iNOS ranges from 4-65 µM.3,5 L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC50 of 0.54 µM.6,7 |
| 别名 | L-NG-Nitroarginine methyl ester;N(G)-Nitro-L-arginine methyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Griffith, O.W., and Kilbourn, R.G. Nitric oxide synthase inhibitors: Amino acids. Methods in Enzymology 268, 375-392 (1996). 2.Buckner, C.K.,Saban, R.,Castleman, W.L., et al. Analysis of leukotriene receptor antagonists on isolated human intralobar airways. Annals of the New York Academy of Sciences 524, 181-186 (1988). 3.Furfine, E.S.,Harmon, M.F.,Paith, J.E., et al. Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine. Biochemistry 32, 8512-8517 (1993). 4.Garvey, E.P.,Tuttle, J.V.,Covington, K., et al. Purification and characterization of the constitutive nitric oxide synthase from human placenta. Archives of Biochemistry and Biophysics 311, 235-241 (1994). 5.Abu-Soud, H.M.,Feldman, P.L.,Clark, P., et al. Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction. The Journal of Biological Chemisty 269, 32318-32326 (1994). 6.Rees, D.D.,Palmer, R.M.J.,Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. British Journal of Pharmacology 101, 746-752 (1990). 7.Moore, P.K.,al-Swayeth, O.A.,Chong, N.W.S., et al. L-NG-Nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. British Journal of Pharmacology 99, 408-412 (1990). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 269.7 |
| 分子式 | C7H15N5O4 • HCl |
| CAS号 | 51298-62-5 |
| 稳定性 | ≥ 1 year |
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