C-8 Ceramide
货号：
62540-1mg 基本售价：
140.0 元 规格：
1 mg
产品信息
概述| 货号 | 62540-1mg |
| 描述 | C-8 ceramide is a cell-permeable analog of naturally occurring ceramides. Unlike C-2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels.1 For this reason, treatment of cells with C-8 ceramide may more closely mimic the effects of ceramide elevation than does treatment with shorter chain ceramide analogs. C-8 ceramide likely mediates many diverse biological activities, as do natural ceramides. It promotes the differentiation of human keratinocytes2 and induces apoptosis of both human leukemia cells and the U937 cell line.1,3 |
| 别名 | C8 Ceramide (d18:1/8:0);N-octanoylsphingosine;N-octanoyl-D-erythro-sphingosine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Karasavvas, N.,Erukulla, R.K.,Bittman, R., et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. European Journal of Biochemistry 236, 729-737 (1996).
2.Wakita, H.,Tokura, Y.,Yagi, H., et al. Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine. Archives of Dermatological Research 286, 350-354 (1994).
3.Geley, S.,Hartmann, B.L., and Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Letters 400, 15-18 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 425.7 |
| 分子式 | C26H51NO3 |
| CAS号 | 74713-59-0 |
| 稳定性 | ≥ 1 year |
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