| 货号 | 62525-1mg |
| 描述 | C-6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C-2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides.1 C-6 ceramide mediates many diverse biological activities including apoptosis,2 activation of protein phosphatase 2A,1,3 and inhibition of the mitochondrial respiratory chain.4 It also enhances the expression of COX-2 in rat granulosa cells5 and stimulates the growth of bovine aortic smooth muscle cells.6 C-6 ceramide acts in neuronal axons to inhibit neurite growth.7 |
| 别名 | C6 Ceramide (d18:1/6:0);N-Caproyl-C18-sphingosine;N-hexanoyl-D-erythro-sphingosine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dobrowsky, R.T., and Hannun, Y.A. Ceramide stimulates a cytosolic protein phosphatase. The Journal of Biological Chemisty 267(8), 5048-5051 (1992). 2.Cai, Z.,Bettaieb, A.,El Mahdani, N., et al. Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-α-mediated cytotoxicity. The Journal of Biological Chemisty 272(11), 6918-6926 (1997). 3.Dobrowsky, R.T.,Kamibayashi, C.,Mumby, M.C., et al. Ceramide activates heterotrimeric protein phosphatase 2A. The Journal of Biological Chemisty 268(21), 15523-15530 (1993). 4.Gudz, T.I.,Tserng, K.Y., and Hoppel, C.L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272(39), 24154-24158 (1997). 5.Santana, P.,Llanes, L.,Hernandez, I., et al. Interleukin-1β stimulates sphingomyelin hydrolysis in cultured granulosa cells: Evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis. Endocrinology 137(6), 2480-2489 (1996). 6.Augé, N.,Andrieu, N.,Nègre-Salvayre, A., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271(32), 19251-19255 (1996). 7.Posse de Chaves, E.I.,Bussière, M.,Vance, D.E., et al. Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. The Journal of Biological Chemisty 272(4), 2038-3035 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.6 |
| 分子式 | C24H47NO3 |
| CAS号 | 124753-97-5 |
| 稳定性 | ≥ 1 year |
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