| 货号 | 62510-1mg |
| 描述 | C-2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,1 induction of apoptosis,2 activation of protein phosphatase 2A,3 and inhibition of the mitochondrial respiratory chain.4 C-2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts5 and stimulates the growth of bovine aortic smooth muscle cells.6 The ability of C-2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.7 |
| 别名 | C2 Ceramide (d18:1/2:0);N-acetoyl-D-erythro-sphingosine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Okazaki, T.,Bielawska, A.,Bell, R.M., et al. Role of ceramide as a lipid mediator of 1α,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. The Journal of Biological Chemisty 265, 15823-15831 (1990). 2.Obeid, L.M.,Linardic, C.M.,Karolak, L.A., et al. Programmed cell death induced by ceramide. Science 259, 1769-1771 (1993). 3.Dobrowsky, R.T.,Kamibayashi, C.,Mumby, M.C., et al. Ceramide activates heterotrimeric protein phosphatase 2A. The Journal of Biological Chemisty 268(21), 15523-15530 (1993). 4.Gudz, T.I.,Tserng, K.Y., and Hoppel, C.L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272(39), 24154-24158 (1997). 5.Ballou, L.R.,Chao, C.P.,Holness, M.A., et al. Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. The Journal of Biological Chemisty 267, 20044-20050 (1992). 6.Augé, N.,Andrieu, N.,Nègre-Salvayre, A., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271(32), 19251-19255 (1996). 7.Simon, C.G., Jr., and Gear, A.R.L. Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation. Biochemistry 37, 2059-2069 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 341.5 |
| 分子式 | C20H39NO3 |
| CAS号 | 3102-57-6 |
| 稳定性 | ≥ 1 year |
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