| 货号 | 20756-5g |
| 描述 | Deoxycholic acid (DCA) is a secondary bile acid produced from cholic acid (Item No. 20250) by bacterial action in the colon.1 It is usually conjugated with glycine or taurine and acts as a detergent in the emulsification of fats for intestinal absorption.2,3 Elevated levels of DCA are strongly associated with the development of colon cancer.4 |
| 别名 | Cholanoic Acid;DCA;NSC 8797; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Huang, J.,Bathena, S.P.R.,Csanaky, I., et al. Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. Journal of Pharmaceutical & Biomedical Analysis 55(5), 1111-1119 (2011). 2.Zhang, Y. and Klaassen, C.D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. Journal of Lipid Research 51(11), 3230-3242 (2010). 3.Semba, R.D.,Gonzalez-Freier, M.,Moaddel, R., et al. Environmental enteric dysfunction is associated with altered bile acid metabolism. J.Pediatr.Gastenterol.Nutr. (2016). 4.Centuori, S.M. and Martinez, J.D. Differential regulation of EGFR-MAPK signaling by deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) in colon cancer. Dig. Dis. Sci. 59(10), 2367-2380 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 392.6 |
| 分子式 | C24H40O4 |
| CAS号 | 83-44-3 |
| 稳定性 | ≥ 2 years |
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