OMDM-1
货号：
10171-1mg 基本售价：
140.0 元 规格：
1 mg
产品信息
概述| 货号 | 10171-1mg |
| 描述 | Numerous analogs of arachidonoyl ethanolamide1 (AEA, anandamide; Item No. 90050) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.2 OMDM-1 is an endocannabinoid analog specifically designed to be a potent and selective inhibitor of the cellular uptake of AEA.3 Structurally, OMDM-1 is the amide of (S)-tyrosinol with oleic acid (Item No. 90260). In RBL-2H3 cells, OMDM-1 inhibits the cellular uptake of tritiated AEA with an IC50 of 2.4 µM, with negligible effects on the CB1 receptor and VR1.3 |
| 别名 | (S)-N-oleoyl Tyrosinol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Khanolkar, A.D. and Makriyannis, A. Structure-activity relationships of anandamide, an endogenous cannabinoid ligand. Life Sciences 65, 607-616 (1999).
2.Deutsch, D.G.,Glaser, S.T.,Howell, J.M., et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. The Journal of Biological Chemisty 276(10), 6967-6973 (2001).
3.Ortar, G.,Ligresti, A.,De Petrocellis, L., et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochemical Pharmacology 65, 1473-1481 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 431.7 |
| 分子式 | C27H45NO3 |
| CAS号 | 616884-62-9 |
| 稳定性 | ≥ 2 years |
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