Thioperamide (maleate)
货号：
10011127-1mg 基本售价：
140.0 元 规格：
1 mg
产品信息
概述| 货号 | 10011127-1mg |
| 描述 | Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg.1 At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Meir, G.,Apelt, J.,Reichert, U., et al. Influence of imidazole replacement in different structural classes of histamine H3-receptor antagonists. European Journal of Pharmaceutical Sciences 13, 249-259 (2001).
2.Harada, C.,Fujii, Y.,Hirai, T., et al. Inhibitory effect of iodophenprofit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. Brain Research Bulletin 63, 143-146 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 408.5 |
| 分子式 | C15H24N4S • C4H4O4 |
| CAS号 | 148440-81-7 |
| 稳定性 | ≥ 2 years |
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