2-PCPA (hydrochloride)
货号：
10010494-10mg 基本售价：
140.0 元 规格：
10 mg
产品信息
概述| 货号 | 10010494-10mg |
| 描述 | Histones contain unstructured N-terminal residues that are the site of numerous post-translational modifications, involving acetylation, methylation, ubiquitination, and sumoylation to produce a specific gene regulatory outcome.1 Complementary enzymes catalyze the addition and removal of these modifications as needed. The amine oxidase domain-containing enzyme lysine-specific demethylase 1 (LSD1) is a member of one of two classes of histone demethylases capable of demethylating lysine residues.1 LSD1 shares similar catalytic sites with monoamine oxidases (MAO) A and B, the inhibition of which are used clinically to treat depression, anxiety, and Parkinson’s disease.2 2-PCPA is an irreversible, mechanism-based inhibitor of LSD1 with an IC50 value of 20.7 µM and a Ki value of 242.7 µM that effectively inhibits histone demethylation in vivo.3 Although not as selective, 2-PCPA also irreversibly inhibits monoamine oxidase (MAO) A and MAO B with IC50 values of 2.3 and 0.95 µM and Ki values of 101.9 and 16 µM, respectively.3 |
| 别名 | trans-2-Phenylcyclopropylamine;Tranylcypromine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Forneris, F.,Binda, C.,Vanoni, M.A., et al. Human histone demethylase LSD1 reads the histone code. The Journal of Biological Chemisty 280(50), 41360-41365 (2005).
2.Lee, M.G.,Wynder, C.,Schidt, D.M., et al. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chemistry & Biology 13, 563-567 (2006).
3.Schmidt, D.M.Z. and McCafferty, D.G. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 46, 4408-4416 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 169.7 |
| 分子式 | C9H11N • HCl |
| CAS号 | 1986-47-6 |
| 稳定性 | ≥ 2 years |
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