| 货号 | 80310-5mg |
| 描述 | L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively.1,2,3 L-NIL effectively inhibits iNOS both in vitroandin vivo.4,5,3 L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.3,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moore, W.M.,Webber, R.K.,Jerome, G.M., et al. L-N6-(1-Iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase. Journal of Medicinal Chemistry 37, 3886-3888 (1994). 2.Grant, S.K.,Green, B.G.,Stiffey-Wilusz, J., et al. Structural requirements for human inducible nitric oxide synthase substrates and substrate analogue inhibitors. Biochemistry 37, 4174-4180 (1998). 3.Stenger, S.,Thuring, H.,Rollinghoff, M., et al. L-N6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo. European Journal of Pharmacology 294(2-3), 703-712 (1995). 4.Budziñski, M.,Misterek, K.,Gumulka, W., et al. Inhibition of inducible nitric oxide synthase in persistent pain. Life Sciences 66, 301-305 (2000). 5.Faraci, W.S.,Nagel, A.A.,Verdries, K.A., et al. 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. British Journal of Pharmacology 119, 1101-1108 (1996). 6.Diefenbach, A.,Schindler, H.,Donhauser, N., et al. Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8(1), 77-87 (1998). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 260.2 |
| 分子式 | C8H17N3O2 • 2HCl |
| CAS号 | 159190-45-1 |
| 稳定性 | ≥ 2 years |
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