| 货号 | 70730-5mg |
| 描述 | Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARα,1,2,3 it activates PPARγ as well.4 Activation of PPARδ by Wy 14643 is also observed,5 but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.6 |
| 别名 | Pirinixic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Devchand, P.R.,Keller, H.,Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 384, 39-43 (1996). 2.Hsu, M.H.,Palmer, C.N.A.,Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators. Molecular Pharmacology 48, 559-567 (1995). 3.Staels, B.,Koenig, W.,Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 393, 790-793 (1998). 4.Lehmann, J.M.,Lenhard, J.M.,Oliver, B.B., et al. Peroxisome proliferator-activated receptors α and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. The Journal of Biological Chemisty 272, 3406-3410 (1997). 5.Schmidt, A.,Endo, N.,Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Molecular Endocrinology 6, 1634-1641 (1992). 6.Keller, H.,Devchand, P.R.,Perroud, M., et al. PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biological Chemistry 378, 651-655 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 323.8 |
| 分子式 | C14H14ClN3O2S |
| CAS号 | 50892-23-4 |
| 稳定性 | ≥ 2 years |
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