AL 34662
货号：
10011546-1mg 基本售价：
126.0 元 规格：
1 mg
产品信息
概述| 货号 | 10011546-1mg |
| 描述 | The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated via at least six major 5-HT receptor subtypes, including 5-HT2 AL 34662 is a potent 5-HT2 receptor agonist with ocular hypotensive activity. It binds to the human and rat 5-HT2 receptors in cerebral cortex homogenates with IC50 values of 1.5 and 0.77 nM, respectively.1 AL 34662 binds to the recombinant human 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 14.5, 8.1, and 3 nM, respectively. In ocular hypertensive cynomolgus monkey eyes, AL 34662 lowered intraocular pressure (IOP) 25% at a dose of 100 µg and 33% at 300 µg (six hours post dose) with minimal side effects.1 |
| 别名 | AL 34497; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sharif, N.A.,McLaughlin, M.A. and Kelly, C.R. AL-34662: A potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. Journal of Ocular Pharmacology and Therapeutics 23(1), 1-13 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 191.2 |
| 分子式 | C10H13N3O |
| CAS号 | 210580-75-9 |
| 稳定性 | ≥ 2 years |
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