Erbstatin analog
货号：
10010238-1mg 基本售价：
126.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010238-1mg |
| 描述 | Overactivity of the epidermal growth factor (EGF) receptor-associated tyrosine kinase has been associated with a number of cancers and thus tyrosine kinase inhibitors could be potential therapeutic agents to prevent malignant growth.1 Erbstatin is a potent, small-molecule inhibitor of EGF receptor-associated tyrosine kinase. However, it is highly unstable, inactivating completely within 30 minutes in calf serum.2 Erbstatin analog is a stable, potent inhibitor of EGFR kinase activity. It is four-times more stable than erbstatin in calf serum2 and inhibits EGFR tyrosine kinase in vitro similar to erbstatin with an IC50 value of 0.14 µg/ml.2 Erbstatin analog inhibits EGF-stimulated growth in EGFR-overexpressing NIH3T3 cells with an IC50 value of 0.5 µg/ml and efficiently delays the onset of EGF-induced DNA synthesis.3 |
| 别名 | Methyl 2,5-dihydoxycinnamate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sausville, E.A.,Elsayed, Y.,Monga, M., et al. Signal transduction-directed cancer treatments. Annual Reviews of Pharmacology and Toxicology 43, 199-231 (2003).
2.Umezawa, K.,Hori, T.,Tajima, H., et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Letters 260(2), 198-200 (1990).
3.Umezawa, K.,Sugata, D.,Yamashita, K., et al. Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells. FEBS Letters 314(3), 289-292 (1992).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 194.2 |
| 分子式 | C10H10O4 |
| CAS号 | 63177-57-1 |
| 稳定性 | ≥ 2 years |
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