| 货号 | 62120-1mg |
| 描述 | ATK is an analog of arachidonic acid in which the carboxyl group is replaced by a trifluoromethyl ketone group.1 It inhibits the activity of the 85 kDa cPLA2 and the 80 kDa macrophage iPLA2 without altering the activity of the 14 kDa sPLA2s.1,2,3 ATK is useful for differentiating the effects of cPLA2 and iPLA2 from sPLA2.4,5 |
| 别名 | ATK;AATFMK; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Street, I.P.,Lin, H.K.,Laliberté, F., et al. Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry 32, 5935-5940 (1993). 2.Ackermann, E.J.,Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. The Journal of Biological Chemisty 270, 445-450 (1995). 3.Conde-Frieboes, K.,Reynolds, L.J.,Lio, Y.C., et al. Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A2. Journal of the American Chemical Society 118, 5519-5525 (1996). 4.Bartoli, F.,Lin, H.K.,Ghomashchi, F., et al. Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets. The Journal of Biological Chemisty 269, 15625-15630 (1994). 5.Riendeau, D.,Guay, J.,Weech, P.K., et al. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. The Journal of Biological Chemisty 269, 15619-15624 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.5 |
| 分子式 | C21H31F3O |
| CAS号 | 149301-79-1 |
| 稳定性 | ≥ 1 year |
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