| 货号 | 89540-1000mg |
| 描述 | Nitrotyrosine is formed by peroxynitrite-mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation in vivo.1,2,3,4 Both free and protein-bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions.2,5,6 The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by gas chromatography/mass spectrometry.7,8 |
| 别名 | NT; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beckman, J.S. and Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. American Journal of Physiology 271, C1424-C1437 (1996). 2.Beckman, J.S.,Ye, Y.Z.,Anderson, P.G., et al. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biological Chemistry of Hoppe-Seyler 375, 81-88 (1994). 3.Abe, K.,Pan, L.H.,Watanabe, M., et al. Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis. Neurological Research 19, 124-128 (1997). 4.Ferrante, R.J.,Shinobu, L.A.,Schulz, J.B., et al. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Annals of Neurology 42, 326-334 (1997). 5.Haddad, I.Y.,Pataki, G.,Hu, P., et al. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury. Journal of Clinical Investigation 94, 2407-2413 (1994). 6.Ohya, M.,Marukawa, S.,Inoue, T., et al. Plasma nitrotyrosine concentration relates to prognosis in human septic shock. Shock 18(2), 116-118 (2002). 7.Tsikas, D.,Schwedhelm, E.,Stutzer, F.K., et al. Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometry. Journal of Chromatography B 784, 77-90 (2003). 8.Schwedhelm, E.,Tsikas, D.,Gutzki, F.M., et al. Gas chromatographic-tandem mass spectrometric quantification of free 3-nitrotyrosine in human plasma at the basal state. Analytical Biochemistry 276, 195-203 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 226.2 |
| 分子式 | C9H10N2O5 |
| CAS号 | 621-44-3 |
| 稳定性 | ≥ 2 years |
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