Lisinopril
货号：
16833-100mg 基本售价：
98.0 元 规格：
100 mg
产品信息
概述| 货号 | 16833-100mg |
| 描述 | Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes.1 Lisinopril is a potent ACE inhibitor that blocks the formation of angiotensin I with an IC50 value of 1.2 nM (ovine) and displays ID50 values of 2.3 and 6.5 µg/kg in rat and canine, respectively.2 At 0.1 nM lisinopril reduces the formation of endothelin-1 and increases nitric oxide in human vascular endothelial cells.3 |
| 别名 | MK-521;MK-522; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zaman, M.A.,Oparil, S. and Calhoun, D.A. Drugs targeting the renin-angiotensin-aldosterone system. Nature Reviews.Drug Discovery 1, 621-636 (2002).
2.Patchett, A.A.,Harris, E.,Tristram, E.W., et al. A new class of angiotensin-converting enzyme inhibitors. Nature 288, 280-283 (1980).
3.Desideri, G.,Grassi, D.,Croce, G., et al. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: Evidence of an oxidant-sensitive pathway. Mediators of Inflammation (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 405.5 |
| 分子式 | C21H31N3O5 |
| CAS号 | 76547-98-3 |
| 稳定性 | ≥ 2 years |
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