| 货号 | 10007852-100mg |
| 描述 | Pargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension.1,2 At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats.3 The correlation between the fall of blood pressure and the inhibition of brain MAO suggests that the accumulation of amine in brain is responsible for the fall in pressure.4 Reactive oxygen species-mediated monocyte hypertrophy is prevented by pargyline at a concentration of 10 µM.1 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bianchi, P.,Pimentel, D.R.,Murphy, M.P., et al. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation. The FASEB Journal 1-15 (2005). 2.Puig, M.,Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA. Journal of Pharmacology and Experimental Therapeutics 182(1), 130-134 (1972). 3.Fuentes, J.A.,Ordaz, A., and Neff, N.H. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. European Journal of Pharmacology 57, 21-27 (1979). 4.Yamori, Y.,De Jong, W.,Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats. Journal of Pharmacy and Pharmacology 24, 690-695 (1972). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 195.7 |
| 分子式 | C11H13N • HCl |
| CAS号 | 306-07-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |