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货号： bs-1498R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-1498R
- 英文名称
- FASN
- 中文名称
- 脂肪酸合成酶抗体
- 别 名
- fatty acid synthase; FASN; FAS; FA Synthase 1; MGC14367; MGC15706; OA-519; Fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase; FAS_MOUSE.
- Specific References (3) | bs-1498R has been referenced in 3 publications.[IF=1.65] Zhu, J. J., et al. "Inhibition of FASN reduces the synthesis of medium-chain fatty acids in goat mammary gland." Animal (2014): 1-10. other ;PubMed:24909980[IF=3.23] Chen Z, Luo J, Ma L, Wang H, Cao W, Xu H, et al. (2015) MiR130b-Regulation of PPARγ Coactivator- 1α Suppresses Fat Metabolism in Goat Mammary Epithelial Cells. PLoS ONE 10(11): e0142809 WB ; Goat.PubMed:26579707[IF=3.23] Li M, Ye T, Wang X-X, Li X, Qiang O, Yu T, et al. (2016) Effect of Octreotide on Hepatic Steatosis in Diet-Induced Obesity in Rats. PLoS ONE 11(3): e0152085 IHC-P ; Rat.PubMed:27002331
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 肿瘤 心血管 免疫学 神经生物学 信号转导 激酶和磷酸酶 合成与降解
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 272kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse FASN:651-750/2511
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
FASN (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis. FAS is a target for SREBP and is upregulated by LXR activation; it is also one of the accepted markers for insulin resistance, SREBP and LXR activation.
Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Subunit:
Homodimer which is arranged in a head to tail fashion.
Subcellular Location:
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity:
Ubiquitous. Prominent expression in brain, lung, and liver.
Similarity:
Contains 1 acyl carrier domain.
SWISS:
P19096
Gene ID:
14104
Database links:Entrez Gene: 2194 Human
Entrez Gene: 14104 Mouse
Entrez Gene: 50671 Rat
Entrez Gene: 281152 Cow
Omim: 600212 Human
SwissProt: P12276 Chicken
SwissProt: Q71SP7 Cow
SwissProt: P49327 Human
SwissProt: P19096 Mouse
SwissProt: P12785 Rat
Unigene: 8951 Chicken
Unigene: 30099 Cow
Unigene: 83190 Human
Unigene: 236443 Mouse
Unigene: 9486 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
合成与降解（Synthesis and Degradation）
脂肪酸合成酶fatty acid synthase是一种新的肿瘤标志物,高表达常提示肿瘤的预后不良.
- 产品图片
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-FASN Polyclonal Antibody, Unconjugated(bs-1498R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining