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货号： bs-3908R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3908R-Bio
- 英文名称
- Anti-LTA4H/Biotin
- 中文名称
- 生物素标记的白三烯A4水解酶抗体
- 别 名
- Leukotriene A4 hydrolase LTA4; LTA4 hydrolase; LTA4H; LKHA4_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 69kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LTA4H
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Leukotrienes are a group of bioactive compounds which play important roles in immediate hyposensitivity reactions and inflammation. Leukotriene A4 hydrolase hydrolyzes an epoxide moiety of leukotriene A4 (LTA4) to form leukotriene B4 (LTB4). The enzyme also has some peptidase activity.
Function:
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
Post-translational modifications:
Phosphorylation at Ser-416 inhibits enzymatic activity.
Similarity:
Belongs to the peptidase M1 family.
Database links:Entrez Gene: 4048Human
Entrez Gene: 299732Rat
Omim: 151570Human
SwissProt: P09960Human
SwissProt: P30349Rat
Unigene: 524648Human
Unigene: 104990Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白三烯A4水解酶是一种含锌的金属蛋白酶，是水解白三烯A4（LTA4）产生白三烯B4的关键酶（LTB4），LTB4是参与炎症反应的主要物质。LTA4H还具有内在的氨基肽酶活性。 目前LTA4H发挥氨基肽酶活性的底物和生理学功能尚不清楚。