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货号： bs-1065R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-1065R
- 英文名称
- C9orf127
- 中文名称
- 鼻咽癌细胞相关基因6抗体
- 别 名
- NGX6; 4930500O05Rik; C9orf127; MGC120460; NAG-5; NGX6; RGD1310012; RP11-112J3.10; TMEM8B; nasopharyngeal carcinoma; NPC associated gene 6; TMM8B_HUMAN; chromosome 9 open reading frame 127; NAG 5; Nasopharyngeal carcinoma expressed 6; Nasopharyngeal carcinoma related protein; Nasopharyngeal carcinoma-associated gene 6 protein; Protein NAG-5; Protein NGX6; RP11-112J3.10; RP11-112J3.10-001; TMEM8B; Transmembrane protein 8B .
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 52kDa
- 细胞定位
- 细胞核 细胞浆 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NGX6:21-120/472
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
NGX6 (nasopharyngeal carcinoma/NPC associated gene 6) may function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. [SUBUNIT] Isoform 2 (via its cytoplasmic part) interacts with EZR. [SUBCELLULAR LOCATION] Isoform 2: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasm (Probable). Nucleus (Probable). Mitochondrion. Endoplasmic reticulum. Belongs to the NGX6 family.
The down-regulation of C9orf127 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. However, it may not contribute to the development and progression of gastric carcinoma.
Function:
May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.
Subunit:
Isoform 2 (via its cytoplasmic part) interacts with EZR.
Subcellular Location:
Cell membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Also detected in mitochondrion and endoplasmic reticulum.
Post-translational modifications:
Isoform 2 is N-glycosylated.
Similarity:
Belongs to the TMEM8 family.
Contains 1 EGF-like domain.
SWISS:
A6NDV4
Gene ID:
51754
Database links:Entrez Gene: 51754Human
Entrez Gene: 100125302Cow
Entrez Gene: 242409Mouse
Entrez Gene: 313490Rat
SwissProt: A6QLK4Cow
SwissProt: A6NDV4Human
SwissProt: B1AWJ5Mouse
Unigene: 493808Human
Unigene: 171489Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NGX6是鼻咽癌发生和发展重要的相关蛋白,NGX-6作用于鼻咽癌细胞，抗体可用于鼻咽癌诊断。有学者认为：NGX6也表达在部分消化系统的肿瘤中。
- 产品图片
Tissue/cell: human nasopharyngeal carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-NGX6/C9orf127 Polyclonal Antibody, Unconjugated(bs-1065R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining