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货号： bs-1193R 基本售价： 380.0 元 规格： 20ul
- 规格：20ul
- 价格：380.00元
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-1193R
- 英文名称
- IL-23
- 中文名称
- 白介素-23抗体
- 别 名
- IL 23; IL 23A; IL23P19; Interleukin 23 alpha subunit p19; JKA3 induced upon T cell activation; P19; SGRF; IL-23 subunit alpha; IL-23-A; IL-23p19; IL23; Il23a; IL23A_HUMAN; Interleukin 23 p19 subunit; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T cell activation; MGC79388; P19.
- Specific References (3) | bs-1193R has been referenced in 3 publications.[IF=1.37] Yang, Xiao, et al. "Effect of Iodine Excess on Th1, Th2, Th17, and Treg Cell Subpopulations in the Thyroid of NOD. H-2h4 Mice." Biological Trace Element Research (2014): 1-9. IHC-P ; Mouse.PubMed:24740393[IF=2.38] Sun, Jiabing, et al. "A Crucial Role of IL-17 in Bone Resorption During Rejection of Fresh Bone Xenotransplantation in Rats." Cell Biochemistry and Biophysics: 1-7. IHC-P ; Rat.PubMed:25331672[IF=3.33] Wang, Mingfei, et al. "Damage effect of Interleukin (IL)-23 on oxygen-glucose deprived cells of the neurovascular unit via IL-23 receptor." Neuroscience (2015). IHC-P ; Mouse.PubMed:25600958
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IL-23:101-196/196
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
IL23 is a heterodimeric cytokine consisting in two subunits : p40, shared with IL12 and a distinct one p19 (the IL23 subunit). Although IL12 activates naive T cells, the initial description of IL23 was the preferential action on memory T cells to increase IFNg production. In conjunction with IL6 and TGF-beta1, IL23 is necessary to maintain the Th1 lineage. IL23 plays an important role in the inflammatory response against infection, and is implicated in the development of cancerous tumors and auto immune diseases. Over expression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin.
Function:
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Subcellular Location:
Secreted. Secreted upon association with IL12B.
Tissue Specificity:
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Similarity:
Belongs to the IL-6 superfamily.
SWISS:
Q9NPF7
Gene ID:
51561
Database links:Entrez Gene: 51561Human
Entrez Gene: 83430Mouse
Omim: 605580Human
SwissProt: Q9NPF7Human
SwissProt: Q9EQ14Mouse
Unigene: 382212Human
Unigene: 98309Human
Unigene: 125482Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IL23(Interleukin-23)作为一种前炎症细胞因子，具有影响机体免疫反应和抗感染作用,白介素23能连接肿瘤关联的炎症和肿瘤免疫监督缺乏关系的细胞因子。存在于很多人类肿瘤中，能通过促进血管形成来帮助肿瘤生长。
- 产品图片
Tissue/cell: human rhinopolypus tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-IL-23 Polyclonal Antibody, Unconjugated(bs-1193R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining