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货号： bs-0711R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-0711R
- 英文名称
- FAM3B
- 中文名称
- 胰腺衍生因子抗体
- 别 名
- C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 免疫学 细胞凋亡 糖尿病
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 23kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FAM3B:1-100/235
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family.
Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
Subcellular Location:
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
Tissue Specificity:
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.
Post-translational modifications:
2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
O-glycosylated.
Similarity:
Belongs to the FAM3 family.
SWISS:
Q9D309
Gene ID:
52793
Database links:Entrez Gene: 54097 Human
Entrez Gene: 52793 Mouse
Omim: 608617 Human
SwissProt: P58499 Human
SwissProt: Q9D309 Mouse
Unigene: 473877 Human
Unigene: 670704 Human
Unigene: 327932 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胰腺衍生因子（PANcreatic DERived fa*ctor，PANDER）是新发现的一种新型的胰岛细胞因子、由胰岛α细胞和β细胞分泌的一种分泌型细胞因子，与β细胞凋亡密切相关，可以诱导胰岛素分泌β细胞，主要用于糖尿病的研究。
- 产品图片
Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-FAM3B/PANDER Polyclonal Antibody, Unconjugated(bs-0711R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining