产品中心
当前位置：首页>产品中心Anti-Calcitonin receptor
货号： bs-0124R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-0124R
- 英文名称
- Calcitonin receptor
- 中文名称
- 降钙素受体抗体
- 别 名
- Calcitonin receptor precursor; Calcr; CRT; CT R; CTR; CTR1; CALCR_MOUSE; CT-R; CALCR_HUMAN.
- Specific References (3) | bs-0124R has been referenced in 3 publications.[IF=2.46] Su, Jiansheng, et al. "Ibuprofen Rescues Abnormalities in Periodontal Tissues in Conditional Presenilin 1 and Presenilin 2 Double Knockout Mice."International Journal of Molecular Sciences?14.9 (2013): 18457-18469. IHC-P ; Mouse.PubMed:24018889[IF=3.97] Tsukamoto, Manabu, et al. "Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells." Bone (2016). IHC-P ; Mouse.PubMed:26851124[IF=0.23] Zhou, Zhen, et al. "The effects of ZJXG decoction on the serum CT levels and the expressions of CTR and Cbfα1 in callus of femur fracture rats." Biomedical Research 27.3 (2016): 762-768. IHC-P ; Rat.PubMed:0
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 肿瘤 免疫学 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse Calcitonin receptor:31-120/516 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Function:
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Subunit:
Interacts with GPRASP2.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
SWISS:
P32214
Gene ID:
12311
Database links:Entrez Gene: 799 Human
Entrez Gene: 12311 Mouse
Entrez Gene: 116506 Rat
Omim: 114131 Human
SwissProt: P30988 Human
SwissProt: Q60755 Mouse
SwissProt: P32214 Rat
Unigene: 489127 Human
Unigene: 4642 Mouse
Unigene: 10062 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
降钙素受体（Calcitonin receptor,CT-R)是G蛋白偶联受体，有两种受体亚型，CT-R可与多种配体结合，如CGRP、Amylin、Am等。CT-R在破骨细胞中含量最高，也存在于肾等多种器官组织内。
- 产品图片
Paraformaldehyde-fixed, paraffin embedded (Rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CALCR) Polyclonal Antibody, Unconjugated (bs-0124R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.