用途及描述:科研试剂,广泛应用于分子生物学,药理学等科研方面。雷帕霉素(西罗莫司)是新型大环内酯的抗排斥药物,是目前世界上最新的强效免疫抑制剂。本品抑制由抗原和细胞因子(白介素IL-2、IL-4和IL-15)激发的T淋巴细胞的活化和增殖,它亦抑制抗体的产生。在细胞中,西罗莫司与免疫嗜素,即FK结合蛋白-12(FKBP-12)结合,生成FKBP-12免疫抑制复合物。此复合物与哺乳动物的西罗莫司BA分子(mTOR,一种关键的调节激酶)结合并抑制其活性,从而抑制细胞周期中G1期向S期的发展。
储存条件:-20℃,避光防潮密闭干燥。
Product Description
Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were recently identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12target). Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Enhances apoptosis.SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
PURITY: 98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in chloroform, DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
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货号: R8140 基本售价: 400.0 元 规格: -