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货号： bs-4214R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4214R-Bio
- 英文名称
- Anti-GIRK2/Biotin
- 中文名称
- 生物素标记的G蛋白激活内流钾通道蛋白2抗体
- 别 名
- inwardly rectifying subfamily J member 6; Kir3.2; BIR1; G protein activated inward rectifier potassium channel 2; G protein-activated inward rectifier potassium channel 2; GIRK-2; Inward rectifier K(+) channel Kir3.2; IRK6_HUMAN; KATP-2; Kcnj6; Kcnj7; Potassium channel; Potassium channel inwardly rectifying subfamily J member 6.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 通道蛋白 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 47kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GIRK2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Function:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Subunit:
Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
Database links:Entrez Gene: 3763 Human
Entrez Gene: 16522 Mouse
Entrez Gene: 25743 Rat
Omim: 600877 Human
SwissProt: P48051 Human
SwissProt: P48542 Mouse
SwissProt: P48550 Rat
Unigene: 626242 Human
Unigene: 658533 Human
Unigene: 741904 Human
Unigene: 328720 Mouse
Unigene: 10185 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.