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货号： bs-5711R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5711R-Bio
- 英文名称
- Anti-CCDC106/Biotin
- 中文名称
- 生物素标记的卷曲螺旋结构域蛋白106抗体
- 别 名
- Ccdc106; Coiled-coil domain-containing protein 106; Protein predicted by clone 23882; ZNF581; CC106_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CCDC106
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Function:
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Subunit:
Interacts with p53/TP53.
Subcellular Location:
Nucleus. Note=Colocalizes with p53/TP53.
Database links:Entrez Gene: 29903 Human
Entrez Gene: 232821 Mouse
Entrez Gene: 499071 Rat
Omim: 613478 Human
SwissProt: Q9BWC9 Human
SwissProt: Q3ULM0 Mouse
Unigene: 82482 Human
Unigene: 482157 Mouse
Unigene: 488775 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CCDC106通过与p53蛋白相互作用，促进p53蛋白的降解，导致p53功能失活。CCDC106基因很可能是一个癌基因，CCDC106的高表达可能是导致具有野生型p53肿瘤发生的原因之一。