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货号： bs-5712R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5712R-Bio
- 英文名称
- Anti-FGFR1OP/Biotin
- 中文名称
- 生物素标记的成纤维细胞生长因子受体1原癌基因伴侣蛋白抗体
- 别 名
- FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FGFR1OP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms.
Function:
Required for anchoring microtubules to the centrosomes.
Subunit:
Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin.
Tissue Specificity:
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
DISEASE:
Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
Similarity:
Belongs to the FGFR1OP family.
Contains 1 LisH domain.
Database links:Entrez Gene: 11116 Human
Entrez Gene: 75296 Mouse
Entrez Gene: 365103 Rat
Entrez Gene: 683722 Rat
Omim: 605392 Human
SwissProt: Human
SwissProt: O95684 Human
SwissProt: Q66JX5 Mouse
SwissProt: Q4V7C1 Rat
Unigene: 487175 Human
Unigene: 227250 Mouse
Unigene: 166829 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FGFR1OP蛋白最初是在引起干细胞骨髓增生病的癌蛋白中作为FGFR1的融合伴侣被发现的，目前研究认为，FGFR1OP蛋白在很多组织细胞中都有不同的存在，尤其是以脑, 心，肝，肌肉，肾，小肠，结肠，肾上腺，前列腺，睾丸和胰腺中高表达。