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货号： bs-5739R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5739R-Bio
- 英文名称
- Anti-Cyclin A1/Biotin
- 中文名称
- 生物素标记的周期素A1蛋白抗体
- 别 名
- CCN A1; Cyclin-A1; CCNA 1; CCNA1; CyclinA1; MGC132235; MGC159139.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Cyclin A1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Cyclin A1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A1 is expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. It binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Cyclin A1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.
Function:
Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
Subcellular Location:
Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER.
Similarity:
Belongs to the cyclin family. Cyclin AB subfamily.
Database links:Entrez Gene: 8900 Human
Entrez Gene: 12427 Mouse
Omim: 604036 Human
SwissProt: P78396 Human
SwissProt: Q61456 Mouse
Unigene: 417050 Human
Unigene: 4815 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.