产品中心
当前位置：首页>产品中心Anti-phospho-MLF1 Interacting Protein(Thr78)/Biotin
货号： bs-5753R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5753R-Bio
- 英文名称
- Anti-phospho-MLF1 Interacting Protein(Thr78)/Biotin
- 中文名称
- 生物素标记的磷酸化卡波西氏肉瘤疱疹病毒潜伏核抗原相互作用蛋白1抗体
- 别 名
- MLF1 Interacting Protein/PBIP1(phospho T78); MLF1 Interacting Protein/PBIP1 (phospho T78);MLF1 Interacting Protein (phospho T78); MLF1 Interacting Protein (phospho Thr78); p-MLF1 Interacting Protein (Thr78); CENP U; CENP50; CENPU; centromere protein U; HHV8 LNAIP1; ICEN24; Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1; KLIP-1; KLIP1; KSHV latent nuclear antigen interacting protein 1; KSHV LNAIP1; LNAIP 1; LNAIP-1; MLF1IP1; PBIP1; CENPU_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 肿瘤 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 48kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human MLF1 Interacting Protein around the phosphorylation site of Thr78
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MLF1 Interacting protein (also known as PBIP1, MLF1IP1, KLIP1 or KSHV latent nuclear antigen interacting protein 1) is a component of the CENPA nucleosome-associated complex (CENPA NAC), which plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. This protein is involved in transcriptional repression and interacts with the N-terminal domain of Kaposi Sarcoma Herpesvirus latent nuclear antigen (KSHV LNA).
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.
Subunit:
Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with the N-terminal domain of Kaposis sarcoma-associated herpesvirus latent nuclear antigen (LNA). Interacts with MLF1. Interacts with PLK1.
Subcellular Location:
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
Tissue Specificity:
Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.
Post-translational modifications:
Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.
Database links:Entrez Gene: 617866Cow
Entrez Gene: 79682Human
Entrez Gene: 71876Mouse
Entrez Gene: 306464Rat
Omim: 611511Human
SwissProt: Q2KIW5Cow
SwissProt: Q71F23Human
SwissProt: Q8C4M7Mouse
SwissProt: Q4V8G7Rat
Unigene: 575032Human
Unigene: 217385Mouse
Unigene: 22108Mouse
Unigene: 128609Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.