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货号： bs-4292R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4292R-Bio
- 英文名称
- Anti-BPI/Neutrophil Bactericidal Protein BP30/Biotin
- 中文名称
- 生物素标记的杀菌/通透性增强蛋白抗体
- 别 名
- Bactericidal permeability-increasing protein; bactericidal/permeability-increasing protein; CAP 57; CAP57; rBPI; BPI_HUMAN; BPI fold containing family D, member 1; BPIFD1; Recombinant BPI holoprotein, rBPI.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 细胞凋亡 细菌及病毒 t-淋巴细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BPI
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Subunit:
Monomer. Homodimer; disulfide-linked.
Subcellular Location:
Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue Specificity:
Restricted to cells of the myeloid series.
Similarity:
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Database links:Entrez Gene: 671 Human
Omim: 109195 Human
SwissProt: P17213 Human
Unigene: 529019 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
杀菌／通透性增加蛋白(Bactericidal／permeability-increasing protein，BPI)是哺乳动物中性粒细胞中存在的一种碱性蛋白，BPI能与革兰氏阴性菌脂多糖结合，增加外膜对抗菌药物的通透性，具有中和内毒素和杀灭细菌的生物学作用，在革兰氏阴性菌感染的治疗方面有良好的发展前景。