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货号： bs-5980R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5980R-Bio
- 英文名称
- Anti-n-Myc/Biotin
- 中文名称
- 生物素标记的致癌基因n-Myc抗体
- 别 名
- bHLHe37; Class E basic helix-loop-helix protein 37; MODED; MYCN; MYCN_HUMAN; N myc; N myc proto oncogene protein; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; Neuroblastoma MYC oncogene; NMYC; NMYC proto oncogene protein; ODED; Oncogene NMYC; pp65/67; v myc avian myelocytomatosis viral related oncogene neuroblastoma derived; v myc myelocytomatosis viral related oncogene neuroblastoma derived.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 染色质和核信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 49kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human n-Myc
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008].
Function:
May function as a transcription factor.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.
Subcellular Location:
Nucleus.
DISEASE:
Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
Defects in MYCN are the cause of Feingold syndrome type 1 (FGLDS1) [MIM:164280]. A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Database links:Entrez Gene: 4613Human
Entrez Gene: 18109Mouse
Entrez Gene: 298894Rat
Omim: 164840Human
SwissProt: P04198Human
SwissProt: P03966Mouse
SwissProt: Q63379Rat
Unigene: 25960Human
Unigene: 16469Mouse
Unigene: 81116Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.