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货号： bs-5992R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5992R-Bio
- 英文名称
- Anti-BRCAA1/Biotin
- 中文名称
- 生物素标记的乳腺癌相关抗原BRCAA1抗体
- 别 名
- ARID 4B; ARID domain-containing protein 4B; ARID4B; AT rich interactive domain 4B (Rbp1 like); AT rich interactive domain 4B; BCAA; BRCAA 1; BRCAA1; Breast cancer associated antigen 1; Breast cancer associated antigen BRCAA 1; Breast cancer associated antigen BRCAA1; Breast carcinoma associated antigen; Histone deacetylase complex subunit SAP180; Rb binding protein homolog; RBBP1 L1; RBBP1L1; Rbp 1 like; Rbp1 l1; Rbp1 like; RBP1 like protein; RBP1L; Rbp1l1; Retinoblastoma binding protein 1 like 1; SAP 180; SAP180; SIN3A associated protein 180; ARI4B_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 染色质和核信号 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BRCAA1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
Function:
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Subunit:
Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.
Subcellular Location:
Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells.
Tissue Specificity:
Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
Similarity:
Contains 1 ARID domain.
Database links:
UniProtKB/Swiss-Prot: Q4LE39.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.