产品中心
当前位置：首页>产品中心Anti-PIGR/Biotin
货号： bs-6061R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6061R-Bio
- 英文名称
- Anti-PIGR/Biotin
- 中文名称
- 生物素标记的多聚免疫球蛋白受体抗体
- 别 名
- Hepatocellular carcinoma associated protein TB6; Phosphatidylinositol glycan, class R; PIgR; Poly Ig receptor; Polymeric immunoglobulin receptor; PIGR_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 81kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PIGR
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Function:
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Secretory component: Secreted.
Post-translational modifications:
N-glycosylation is not necessary for Ig binding.
Similarity:
Contains 5 Ig-like V-type (immunoglobulin-like)
Database links:Entrez Gene: 5284 Human
Entrez Gene: 18703 Mouse
Omim: 173880 Human
SwissProt: P01833 Human
SwissProt: O70570 Mouse
Unigene: 497589 Human
Unigene: 276414 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
多聚免疫球蛋白受体（pIgR）属Ⅰ型跨膜糖蛋白，可与多聚免疫球蛋白A和多聚免疫球蛋白M特异性结合，通过穿胞转运，将它们从上皮细胞基底侧膜转运到顶膜，并最终分泌到外分泌液中去. 在此过程中，多聚免疫球蛋白受体的细胞外段被水解，释放出与多聚免疫球蛋白A或多聚免疫球蛋白M相结合的细胞外段（又称为分泌成分）. 分泌成分是sIgA分子的重要组成部分，直接参与sIgA的粘膜防御功能，而且在被动粘膜免疫中也有重要作用. 多聚免疫球蛋白受体通过介导细胞内多聚免疫球蛋白的转运，可以在粘膜的腔面阻止病原体粘附，在上皮细胞内中和病毒，也可以将固有层内的抗原分泌出去.