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货号： bs-4661R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4661R-Bio
- 英文名称
- Anti-CD275/Biotin
- 中文名称
- 生物素标记的诱导协同刺激分子配体CD275抗体
- 别 名
- B7 H2; B7 homolog 2; B7 homologue 2; B7 like protein Gl50; B7 related protein 1; B7-H2; B7-like protein Gl50; B7-related protein 1; ICOS-L; B7H2; B7RP 1; B7RP-1; B7RP1; CD 275; CD275; CD275 antigen; GL 50; GL50; ICOS L; ICOS LG; ICOS ligand; ICOSL; ICOSL_MOUSE; Icoslg; Inducible T cell co stimulator ligand; KIAA0653; LICOS; Transmembrane protein B7 H2 ICOS ligand.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse ICOS-L/B7-H2/CD275
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ICOS ligand is a member of the B7 family and the immunoglobulin superfamily. Human ICOS ligand is expressed by activated monocytes/macrophages and dendritic cells. It binds to a CD28 like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. This interaction plays an important role in the T cell costimulation pathway.
Function:
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Isoform 1 highest expression in lymphoid tissues, such as spleen (mostly in the marginal zone), lymph nodes (particularly in the cortex and in both primary and secondary follicles), thymus (predominantly in the medulla) and Peyer patches (mostly in the follicles), lower levels in many non-lymphoid tissues, such as brain, heart, kidney, liver, lung, skeletal muscle and testis. Present on freshly isolated splenic B-cells, T-cells, dendritic cells and macrophages. The expression of isoform 2 is restricted to heart, spleen and kidney.
Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Database links:
UniProtKB/Swiss-Prot: Q9JHJ8.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
B7协同刺激分子及其相应受体结合所产生的信号在调节T细胞活化及效应性细胞因子分泌中起重要作用，具有负性调节作用的协同刺激分子对免疫应答的适度进行、防止自身免疫疾病的发生具有重要作用。B7H2可协同刺激CD14 + 细胞增殖，并分泌IL-4、IL-5、IFN-β、TNF-α、GM-CSF和IL-10等细胞因子，但不能协同刺激T细胞上调IL-2的分泌。