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货号： bs-6562R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6562R-Bio
- 英文名称
- Anti-PAI1/Biotin
- 中文名称
- 生物素标记的内皮细胞纤溶酶原激活抑制蛋白1抗体
- 别 名
- Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serpin E1; Serpin peptidase inhibitor clade E; Serpine 1; Serpine-1;Serpine1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 激酶和磷酸酶 肿瘤细胞生物标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 45kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PAI1/PLANH1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This inhibitor acts as bait for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
Function:
Serine protease inhibitor. This inhibitor acts as bait for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Subunit:
Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.
Subcellular Location:
Secreted.
Tissue Specificity:
Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells
DISEASE:
Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) . It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.
Similarity:
Belongs to the serpin family.
Database links:Entrez Gene: 5054 Human
Entrez Gene: 18787 Mouse
Entrez Gene: 24617 Rat
Omim: 173360 Human
SwissProt: P05121 Human
SwissProt: P22777 Mouse
SwissProt: P20961 Rat
Unigene: 414795 Human
Unigene: 713079 Human
Unigene: 250422 Mouse
Unigene: 29367 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.