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货号： bs-6736R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6736R-Bio
- 英文名称
- Anti-SOX11/Biotin
- 中文名称
- 生物素标记的转录因子SOX-11蛋白抗体
- 别 名
- SRY (sex determining region Y) box 11; SRY related HMG box gene 11; Transcription factor SOX-11; SOX11_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 干细胞 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 47kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SOX11
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. SOX11 appears to be important in the developing nervous system (SOX11 expression is detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression by 13.5 dpc). SOX11 expression is apparent in the somites,limbs,facial mesenchyme,kidney,lung of the fetal system.
Function:
Transcriptional activator.
Subcellular Location:
Nucleus.
Tissue Specificity:
Mainly expressed in the developing central nervous system.
Similarity:
Contains 1 HMG box DNA-binding domain.
Database links:Entrez Gene: 6664 Human
Entrez Gene: 20666 Mouse
Entrez Gene: 84046 Rat
Omim: 600898 Human
SwissProt: P35716 Human
SwissProt: Q7M6Y2 Mouse
SwissProt: P0C1G9 Rat
Unigene: 432638 Human
Unigene: 41702 Mouse
Unigene: 466344 Mouse
Unigene: 162854 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.