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货号： bs-6812R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6812R-Bio
- 英文名称
- Anti-FMNL1/Biotin
- 中文名称
- 生物素标记的成蛋白相关蛋白1抗体
- 别 名
- C17orf1; C17orf1B; CLL associated antigen KW 13; FHOD4; FMNL; Fnrl; Formin like 1; Formin like; Formin related protein; Frls; KW 13; KW13; Leukocyte formin; MGC133052; MGC1894; MGC21878; FMNL_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 肿瘤细胞生物标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 122kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FMNL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
FMNL1 (Formin-like protein 1) gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cyokinesis, and cell polarity. An alternative splice variant has been described but the full length sequence has not yet been determined. FMNL1 possibly has a role in the control of cell motility and survival of macrophages.
Function:
May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Subunit:
Interacts with RAC1, PFN1 and PFN2.Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1.
Subcellular Location:
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1.
Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post-translational modifications:
Myristoylation mediates membrane localization and blebbing.
Similarity:
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Database links:Entrez Gene: 752 Human
Entrez Gene: 57778 Mouse
Entrez Gene: 287746 Rat
Omim: 604656 Human
SwissProt: O95466 Human
SwissProt: Q9JL26 Mouse
Unigene: 100217 Human
Unigene: 138913 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.