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货号： bs-7051R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7051R-Bio
- 英文名称
- Anti-DENTT/Biotin
- 中文名称
- 生物素标记的细胞分裂核仁蛋白1抗体
- 别 名
- CASK interacting nucleosome assembly protein; CINAP; CDA1; Cell division autoantigen 1 nucleolar protein; CTCL tumor antigen se20-4; DENTT; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; TSPY-like 2; TSPY-like protein 2; Tspyl2; Testis-specific Y-encoded-like protein 2; Cutaneous T-cell lymphoma-associated antigen se20-4; SE20 4; SE204; CTCL-associated antigen se20-4; NP79; TSYL2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 76kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DENTT
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
CASK interacting nucleosome assembly protein (CINAP) modulates gene expression and its abundance in cultured neurons is regulated by synaptic activity. CINAP is widely expressed in different regions of adult mouse brain, including the cerebral cortex, hippocampus, striatum, hypothalamus, cerebellum, and two adult brain regions known to generate progenitor neurons. During early development, CINAP is also expressed in regions where neuronal progenitor cells are actively dividing, the ventricular and subventricular zones, suggesting that in addition to regulating gene expression in mature neurons CINAP may also play a role in dividing cells.
Function:
Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Subunit:
Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.
Subcellular Location:
Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons.
Tissue Specificity:
Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
Post-translational modifications:
Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable).
Similarity:
Belongs to the nucleosome assembly protein (NAP) family.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.