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货号： bs-7517R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7517R-Bio
- 英文名称
- Anti-Natriuretic Peptide Receptor A/Biotin
- 中文名称
- 生物素标记的利钠肽受体A抗体
- 别 名
- NPRA; ANP A; ANP-A; ANPa; ANPR-A; ANPRA; ANPRA_HUMAN; Atrial natriuretic peptide A type receptor; Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor A; Atrial natriuretic peptide receptor type A; Atrionatriuretic peptide receptor A; GC A; GC-A; Guanylate cyclase A; Guanylate cyclase; GUC2A; GUCY2A; Natriuretic peptide A type receptor; Natriuretic peptide receptor A/guanylate cyclase A; NPR 1; NPR A; NPR-A; NPR1; NPRA.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 信号转导 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 113kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Natriuretic Peptide Receptor A
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
Function:
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Subunit:
Homodimer.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Post-translational modifications:
Phosphorylation of the protein kinase-like domain is required for full activation by ANP.
Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 1 guanylate cyclase domain.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 4881 HumanEntrez Gene: 24603 Rat
Omim: 108960 Human
SwissProt: P16066 Human
SwissProt: P18910 Rat
Unigene: 490330 Human
Unigene: 10463 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.