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货号： bs-6315R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6315R-Bio
- 英文名称
- Anti-CTBP2/Biotin
- 中文名称
- 生物素标记的C末端结合蛋白2抗体
- 别 名
- C-terminal-binding protein 2 isoform 1; C terminal binding protein 2; C-terminal-binding protein 2; CtBP2; CTBP2_HUMAN; ribeye.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CTBP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3 untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Function:
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation.
Isoform 2 probably acts as a scaffold for specialized synapses.
Subunit:
Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression. Interacts with PNN, NRIP1 and WIZ.
Subcellular Location:
Nucleus. Cell junction, synapse.
Tissue Specificity:
Ubiquitous. Highest levels in heart, skeletalv muscle, and pancreas.
Similarity:
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Database links:Entrez Gene: 281730Cow
Entrez Gene: 1488Human
Entrez Gene: 13017Mouse
Entrez Gene: 81717Rat
Omim: 602619Human
SwissProt: Q0VCQ1Cow
SwissProt: P56545Human
SwissProt: P56546Mouse
SwissProt: Q9EQH5Rat
Unigene: 501345Human
Unigene: 246240Mouse
Unigene: 389984Mouse
Unigene: 138124Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.