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货号： bs-6793R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6793R-Bio
- 英文名称
- Anti-APPD/Biotin
- 中文名称
- 生物素标记的凋亡诱导蛋白D抗体
- 别 名
- PKHF1_HUMAN; Apoptosis inducing protein D;LAPF;Lysosome associated apoptosis inducing protein containing PH and FYVE domains;MGC4090;PH and FYVE domain containing protein 1;PH domain containing family F member 1;Phafin 1;Pleckstrin homology domain containing family F (with FYVE domain) member 1;Pleckstrin homology domain containing family F member 1;Pleckstrin homology domain containing family F with FYVE domain member 1;PLEKHF1;ZFYVE15;Zinc finger FYVE domain containing protein 15.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
- 产品应用
- IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human APPD/LAPF (75-124aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
APPD is a lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF). It is a representative of a novel family of PH and FYVE domain-containing proteins and induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway.Cellular localization: Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.
Function:
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
Subcellular Location:
Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.
Tissue Specificity:
Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.
Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 PH domain.
Database links:Entrez Gene: 79156 Human
Entrez Gene: 72287 Mouse
Entrez Gene: 308543 Rat
SwissProt: Q96S99 Human
SwissProt: Q3TB82 Mouse
SwissProt: Q68FU1 Rat
Unigene: 466383 Human
Unigene: 58389 Human
Unigene: 333798 Mouse
Unigene: 9380 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.