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货号： bs-6779R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6779R-Bio
- 英文名称
- Anti-phospho-MAP3K9+MAP3K10(Thr312 + Thr266)/Biotin
- 中文名称
- 生物素标记的磷酸化丝裂原活化蛋白激酶3K9抗体
- 别 名
- MAP3K9 +MAP3K10 (phospho T312 + T266); MAP3K9 + MAP3K10(phospho T312 + T266); phospho-MAP3K9(Thr312)/MAP3K10( Thr266); p-MAP3K9; M3K9_HUMAN; M3K10_HUMAN; MAPKKK9; MEKK10; MEKK9; Mitogen activated protein kinase kinase kinase 10; Mitogen activated protein kinase kinase kinase 9; Mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK1; MLK2; MST; PRKE1; Protein kinase MST.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 121/105kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human MAP3K9/MAP3K10 around the phosphorylation site of Thr312/Thr266
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008].
Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Subunit:
Homodimer.
Tissue Specificity:
Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Post-translational modifications:
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.
DISEASE:
May play a role in esophageal cancer susceptibility and/or development.
Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SH3 domain.
Database links:Entrez Gene: 4293Human
Entrez Gene: 4294Human
Entrez Gene: 269881Mouse
Entrez Gene: 338372Mouse
Omim: 600136Human
Omim: 600137Human
SwissProt: P80192Human
SwissProt: Q02779Human
SwissProt: Q3U1V8Mouse
SwissProt: Q66L42Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.