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货号： bs-9469R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9469R-Bio
- 英文名称
- Anti-IRX5/Biotin
- 中文名称
- 生物素标记的Iroquois同源蛋白5抗体
- 别 名
- Homeodomain protein IRX-2A; Homeodomain Protein IRXB2; Iroquois Homeobox Protein 5; Iroquois-class homeodomain protein IRX-5; IRX2A; Irx5; IRX5_HUMAN; IRXB2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 神经生物学 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IRX5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells.
Function:
Establishes the cardiac repolarization gradient by itsrepressive actions on the KCND2 potassium-channel gene. Requiredfor retinal cone bipolar cell differentiation. May regulatecontrast adaptation in the retina and control specific aspects ofvisual function in circuits of the mammalian retina (Bysimilarity). Could be involved in the regulation of both the cellcycle and apoptosis in prostate cancer cells. Involved incraniofacial and gonadal development. Modulates the migration ofprogenitor cell populations in branchial arches and gonads byrepressing CXCL12.
Subcellular Location:
Nucleus.
DISEASE:
Defects in IRX5 are the cause of Hamamy syndrome (HMMS)[MIM:611174]. A sydrome characterized by severe hypertelorism,upslanting palpebral fissures, brachycephaly, abnormal ears,sloping shoulders, enamel hypoplasia, and osteopenia with repeatedfractures. Additional features include myopia, mild to moderatesensorineural hearing loss, gonadal anomalies, and borderlineintelligence.
Similarity:
Belongs to the TALE/IRO homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:Entrez Gene: 10265 Human
Entrez Gene: 54352 Mouse
Entrez Gene: 498918 Rat
Omim: 606195 Human
SwissProt: A2RRB5 Human
SwissProt: P78411 Human
SwissProt: Q9JKQ4 Mouse
Unigene: 435730 Human
Unigene: 101153 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.