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货号： bs-18321R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-18321R
- 英文名称
- LNX2
- 中文名称
- LNX2蛋白抗体
- 别 名
- FLJ12933; FLJ23932; FLJ38000; Ligand of Numb protein X 2; LNX 2; LNX2; LNX2_HUMAN; MGC46315; Numb binding protein 2; Numb-binding protein 2; PDZ domain containing ring finger 1; PDZ domain containing RING finger protein 1; PDZ domain-containing RING finger protein 1; PDZRN 1; PDZRN1.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 76kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LNX2:401-500/690
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
LNX2 (LIGAND OF NUMB PROTEIN X2, PDZ DOMAIN-CONTAINING RING FINGER PROTEIN 1, PDZRN1), which interacts with mammalian Numb and NumbL, contains a RING finger domain, followed by a motif similar to a PTB-binding motif and 4 PDZ domains. Lnx2 and Lnx1 (a proposed relative) are multimodular proteins that bind Numb, a cell fate determinant, through their NPXY motifs. Studies may suggest that Lnx proteins act as molecular scaffolds that promote the aggregation of unrelated, interacting proteins, such as Numb, to definitive subcellular sites. The LNX2 gene maps to chromosome 13q12.2 based on an alignment of the LNX2 sequence with the genomic sequence. Lnx proteins may form large networks by homomeric binding, and their expression patterns overlap with those of the Numb proteins. Furthermore, studies also suggest that the oligomerization of Lnx2 and Numb binding occurs simultaneously.
Subunit:
Interacts with the phosphotyrosine interaction domain of NUMB.
Similarity:
Contains 4 PDZ (DHR) domains.
Contains 1 RING-type zinc finger.
SWISS:
Q8N448
Gene ID:
222484
Database links:Entrez Gene: 222484Human
Omim: 609733Human
SwissProt: Q8N448Human
Unigene: 132359Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
U251(Human) Cell Lysate at 30 ug
Primary: Anti-LNX2 (bs-18321R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 76 kD
Observed band size: 76 kD
Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LNX2) Polyclonal Antibody, Unconjugated (bs-18321R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.