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货号： bs-11642R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11642R-Bio
- 英文名称
- Anti-CALHM1/Biotin
- 中文名称
- 生物素标记的钙平衡调节蛋白1抗体
- 别 名
- CAHM1_HUMAN; Calcium homeostasis modulator 1; Calcium homeostasis modulator protein 1; CALHM1; FAM26C; Family with sequence similarity 26, member C; MGC39514; MGC39617; Protein FAM26C.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 通道蛋白 细胞膜蛋白 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CALHM1/FAM26C
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimers disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010].
Function:
May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.
Subunit:
Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.
Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Colocalizes with HSPA5 at the endoplasmic reticulum.
Tissue Specificity:
Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.
Similarity:
Belongs to the FAM26 family.
Database links:Entrez Gene: 255022Human
Entrez Gene: 546729Mouse
Entrez Gene: 499367Rat
Omim: 612234Human
SwissProt: Q8IU99Human
Unigene: 680365Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.