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货号： bs-11696R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11696R-Bio
- 英文名称
- Anti-HAP40/Biotin
- 中文名称
- 生物素标记的舞蹈症相关蛋白40/凝血因子8相关蛋白/第八因子相关蛋白抗体
- 别 名
- F8a; Coagulation factor 8 associated (intronic transcript) 1; Coagulation factor VIII associated (intronic transcript) 1; CpG island protein; DXS522E; F8a; F8A1; F8A2; F8A3; Factor 8 associated protein; Factor 8 intron 22 protein; Factor VIII associated protein; Factor VIII intron 22 protein; huntingtin associated protein 40; F8I2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HAP40 (2-80aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq, Jul 2008]
Function:
Huntington’s disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the huntingtin protein. Huntingtin co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of huntingtin but is actively targeted to the nucleus in the absence of huntingtin. These observations suggest that HAP40 contributes to the function of normal huntingtin and is a candidate for involvement in the aberrant nuclear localization of mutant huntingtin found in degenerating neurons in Huntington’s disease.
Subcellular Location:
Nuclear.
Database links:Entrez Gene: 474383Human
Entrez Gene: 474384Human
Entrez Gene: 8263Human
Omim: 305423Human
SwissProt: P23610Human
Unigene: 533543Human
Unigene: 731793Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.