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货号： bs-11698R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11698R-Bio
- 英文名称
- Anti-HYPE/Biotin
- 中文名称
- 生物素标记的舞蹈症蛋白相互作用蛋白13抗体
- 别 名
- HIP13; Adenosine monophosphate-protein transferase FICD; AMPylator FICD; FIC domain containing; FIC domain containing protein; FIC domain-containing protein; Fic S phase protein cell division homolog; ficd; FICD_HUMAN; HIP-13; HIP13; Huntingtin interacting protein 13; Huntingtin interacting protein E; Huntingtin interactor protein E; Huntingtin yeast partner E; Huntingtin-interacting protein 13; Huntingtin-interacting protein E.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Horse, Sheep,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 52kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HYPE (161-250aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
Function:
Adenylyltransferase that mediates the addition of adenosine 5-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified.
Subunit:
Interacts with HD.
Subcellular Location:
Membrane; Single-pass membrane protein (Potential).
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the fic family.
Contains 1 fido domain.
Contains 2 TPR repeats.
Database links:Entrez Gene: 11153Human
Entrez Gene: 231630Mouse
Entrez Gene: 288741Rat
SwissProt: Q9BVA6Human
SwissProt: Q8BIX9Mouse
SwissProt: Q6AY47Rat
Unigene: 661891Human
Unigene: 21926Mouse
Unigene: 162153Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.