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货号： bs-11721R-Bio 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11721R-Bio
- 英文名称
- Anti-Capicua/Biotin
- 中文名称
- 生物素标记的Capicua蛋白抗体
- 别 名
- Capicua homolog (Drosophila); Cic; CIC; KIAA0306; Protein capicua homolog; CIC_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 164kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Capicua (1475-1560aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Capicua is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granule cells and regulate normal neuronal development. Disruptions in the the association of Capicua with proteins such as ATXN1 are thought to cause medulloblastoma, the most common form of perdiatric brain tumor arising from irregular growth of granule cells.
Function:
Transcriptional repressor which may play a role in development of the central nervous system (CNS).
Subunit:
Interacts with ATXN1 and ATXN1L
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in fetal brain.
Similarity:
Contains 1 HMG box DNA-binding domain.
Database links:Entrez Gene: 23152Human
SwissProt: Q96RK0Human
Unigene: 388236Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.